SAIF plays anti-angiogenesis via blocking VEGF-VEGFR2-ERK signal in tumor treatment

Shark cartilage was created as a cancer-fighting diet because it believed to have an element that may suppress tumor growth. Due overfishing, sharks become endangered recently, making impossible harvest natural components from shark for therapeutic development research. Previously, we identified peptide SAIF with an-tiangiogenic and anti-tumor effects, successfully expressed in Escherichia coli by using genetic engineering techniques. However, did not elucidate the specific target of its antiangiogenic molecular mechanism, which hindered further drug development. Therefore, this work, exact mechanism action studied various techniques, including cellular vivo animal models, computer-aided simulation, capture, transcriptome sequencing analysis. With VEGF-VEGFR2 interaction preventing activation VEGFR2/ERK signaling pathways, discovered decrease angiogenesis hence significantly limit The findings demonstrated SAIF's strong safety pharmaceutically potential. evidence showed SAIF, is by, potent safe inhibitor might be developed candidate treatment solid tumors such hepatocellular carcinoma other conditions linked angiogenic overgrowth.